Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5272953 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
In this report we describe a simple synthesis of mercaptobenzonitriles from the reaction of fluorobenzonitriles with Na2S in DMF at room temperature and following direct treatment with Zn/HCl. Significantly, 2- and 4-fluorobenzonitriles substituted with chlorine or bromine, but not iodine, undergo selective substitution of fluorine at room temperature to yield synthetically useful halo-substituted mercaptobenzonitriles.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tony Taldone, Pallav D. Patel, Hardik J. Patel, Gabriela Chiosis,