| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5272982 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
Two selectively 18O-labeled phthalides containing 18O either in the carbonyl (i.e., C18O) or in the alkoxy group (i.e., OC-18O) of the lactone ring were prepared in good yields (ca. 70%) from the corresponding methyl 2-(bromomethyl)benzoate and its selectively C18O labeled derivative, respectively, using water-assisted cyclization. The reaction mechanism involving formation of a cyclic carboxonium bromide and its water-assisted decomposition to the lactone is proposed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
JiÅà VáÅa, Illia Panov, Milan Erben, MiloÅ¡ Sedlák, JiÅà Hanusek,