Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
52731 | Catalysis Communications | 2006 | 5 Pages |
Abstract
As a competitive trehalase inhibitor and lead compound with broad uses, validoxylamine A has been increasingly studied for its many possible applications. The process of acid-catalyzed hydrolysis of validamycin A was investigated for production of validoxylamine A. The effects of various acids and substrate concentrations were explored, and the mechanism of acid-catalyzed hydrolysis of validamycin A was proposed. Results demonstrated that the optimal condition of acid hydrolysis of validamycin A included 1 M H2SO4 and a 30% (w/v) initial validamycin A concentration in a 1 h reaction time.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Li-Qun Jin, Ya-Ping Xue, Yu-Guo Zheng, Yin-Chu Shen,