Article ID Journal Published Year Pages File Type
52731 Catalysis Communications 2006 5 Pages PDF
Abstract

As a competitive trehalase inhibitor and lead compound with broad uses, validoxylamine A has been increasingly studied for its many possible applications. The process of acid-catalyzed hydrolysis of validamycin A was investigated for production of validoxylamine A. The effects of various acids and substrate concentrations were explored, and the mechanism of acid-catalyzed hydrolysis of validamycin A was proposed. Results demonstrated that the optimal condition of acid hydrolysis of validamycin A included 1 M H2SO4 and a 30% (w/v) initial validamycin A concentration in a 1 h reaction time.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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