Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273165 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Mycobacterium cell wall consists of three major polysaccharide portions and arabinofuranose (Araf) is present in two of the major portions, arabinogalactan (AG) and lipoarabinomannan (LAM). A peculiar Araf hexasaccharide possessing two β-linked Araf units are present in both AG and LAM polysaccharides. Herein, we report an efficient and concise synthesis of this Araf hexasaccharide using single starting 3,5-TIPDS protected Araf thioglycoside precursor. Double β-glycosylation was achieved using strained cyclic 2-p-methoxybenzyl-3,5-TIPDS Araf thioglycoside donor.
Graphical abstractAn efficient and concise synthesis of Araf hexasaccharide using single starting 3,5-TIPDS protected Araf thioglycoside precursor.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karnakar C. Reddy, Narra Padmaja, Vibha Pathak, Ashish K. Pathak,