| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273206 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Nocathiacin-I is one of the newest members of thiazolyl peptide class of antibiotics. It is a potent inhibitor of bacterial protein synthesis and showed potent in vitro and in vivo Gram-positive antibacterial activity. Understanding of the biosynthesis of natural products is important for improvement of titer and precursor directed biosynthesis for new compounds. Biosynthesis of nocathiacin-I in Amycolatopsis fastidiosa using stable isotope precursor incorporation is described.
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Authors
Sheo B. Singh, Kithsiri Herath, Nathan X. Yu, Andre A. Walker, Neal Connors,