| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273225 | Tetrahedron Letters | 2009 | 6 Pages |
Abstract
Functionalized fused heteroaryl pyrazinones were built up through a novel DBU-catalyzed intramolecular hydroamination reaction of aryl(prop-2-yn-1-yl)-1H-heteroaryl-2-carboxamides. The nucleophilic addition afforded three isomers; two with an exo-cyclic double bond [cis (Z), trans (E)], and a third one with an endo-cyclic double bond. After the carboxamide deprotection, isomerization of the mixture under acidic conditions resulted in a unique isomer.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laura Llauger, Costanza Bergami, Olaf D. Kinzel, Samuele Lillini, Giovanna Pescatore, Caterina Torrisi, Philip Jones,