| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273235 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![MAOS protocols for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines](/preview/png/5273235.png "First Page Preview: MAOS protocols for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines")
Authors
Leslie N. Aldrich, Evan P. Lebois, L. Michelle Lewis, Natalia T. Nalywajko, Colleen M. Niswender, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley,