Article ID Journal Published Year Pages File Type
5273239 Tetrahedron Letters 2009 4 Pages PDF
Abstract

Thiophenol-mediated 7-endo radical cyclization for the synthesis of seven-membered cyclic ethers is described. This method can be successfully applied to synthesize various benzoxepin derivatives, which are present in many natural products as building blocks. Alkenyl radicals are generated from easily available terminal alkynes and thiophenol.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry