| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273261 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
The chemoselective S-alkylation of 2-thiohydantoins is reported. The methodology involves the use of alkyl orthoformates (trimethyl and triethyl) as alkylating agents, which in the presence of Ac2O and ZnCl2 chemoselectively alkylate the thio group whilst other nucleophilic groups present in the thiohydantoins are acetylated simultaneously in moderate to high yields. A plausible mechanism for this reaction is delineated.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi Kumar, Prem M.S. Chauhan,