Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273306 | Tetrahedron Letters | 2013 | 9 Pages |
Abstract
Reactions of 2-cyano-6-(trifluoromethyl)-4-pyrone, 2-cyano-4-pyrone, and 2-cyano-6-methyl-4-pyrone with aliphatic and aromatic amines in ethanol at â20 °C for 2-21 days gave 5-amino-3-oxopent-4-enamides in 28-78% yields, which were cyclized with DMF-DMA in toluene under ambient conditions to afford 4-pyridone-3-carboxamides in 31-70% yields.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dmitrii L. Obydennov, Ekaterina S. Sidorova, Boris I. Usachev, Vyacheslav Ya. Sosnovskikh,