| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273317 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
A straightforward asymmetric synthesis of a new series of 2-hydroxyazetidines/2-hydroxypyrrolidines with excellent diastereoselectivity was developed via enamine catalysis using diphenylprolinol silyl ether. The Mannich-type reaction of chiral enamines with various aldimines/aziridines under mild conditions followed by intramolecular hemiaminalization affords the desired products 2-hydroxyazetidines and 2-hydroxypyrrolidines, respectively, in a one-pot operation. The scope and generality of the reaction was adequately investigated and the conditions were optimized extensively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ankita Rai, Lal Dhar S. Yadav,