| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273338 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
We describe herein an efficient and simple method to synthesize 2-organylselanyl pyridines by reactions of 2-chloropyridines with organylselenols, generated in situ by reaction of diorganyl diselenides, using glycerol as solvent and hypophosphorous acid (H3PO2) as reducing agent. Using this methodology, a range of selenium substituted pyridines was obtained in high yields. The system solvent-reducing agent glycerol/H3PO2 can be easily recovered and reused for five times without loss of efficiency.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Samuel Thurow, Rodrigo Webber, Gelson Perin, Eder J. Lenardão, Diego Alves,