| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273495 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
The reductive amination of several carbonyl compounds (Leuckart reaction) has been performed using N-methylformamide and microwave technology. Under these conditions, a new mechanism is proposed via the initial formation of an imine, followed by reduction to the amine by 'in situ' generated formic acid, and further formylation of the amine. Using this methodology, the formyl derivatives of several secondary amines were obtained in good to excellent yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fructuoso Barba, Javier Recio, Belen Batanero,