| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273507 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A domino S-N and C-N coupling/oxidative aromatization process to synthesize 2-aminothio-phenylpyrimidines and 2-amino-phenylpyrimidines by S-N and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and secondary amines catalyzed by molecular iodine. Remarkably the C-N coupled product was obtained via a desulfitative coupling-aromatization reaction in one-pot reaction.
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Authors
Zheng-Jun Quan, Ying Lv, Zhong-Jie Wang, Zhang Zhang, Yu-Xia Da, Xi-Cun Wang,