| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273527 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The basic structural framework of lamellarin alkaloids, 8,9-dihydro-6H-chromeno[4â²,3â²:4,5]pyrrolo[2,1-a]isoquinoline derivatives, has been obtained in good yields via Grob reaction between 3-nitro-2-(trifluoromethyl)-2H-chromenes and 1,3,3-trimethyl-3,4-dihydroisoquinolines in refluxing isobutanol. When the reaction was carried out in toluene at room temperature, only Michael adducts, as a mixture of two diastereomers, were isolated.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vladislav Yu. Korotaev, Vyacheslav Ya. Sosnovskikh, Igor B. Kutyashev, Alexey Yu. Barkov, Yurii V. Shklyaev,