| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273563 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
Herein, we describe the first total synthesis of fomitellic acid B (2), a potent inhibitor of DNA polymerases α and β. There are two key features in this synthesis: (i) the AB ring system, with all requisite chiral centers, is stereoselectively constructed by means of titanium(III)-mediated radical cascade cyclization of epoxypolyene; and (ii) an enone moiety in the B-ring is generated by isomerization of an olefin followed by allylic oxidation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Makoto Yamaoka, Atsuo Nakazaki, Susumu Kobayashi,