| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273590 | Tetrahedron Letters | 2009 | 5 Pages |
Abstract
A new domino process of three-component Povarov reaction and aerobic dehydrogenation was developed toward the synthesis of polysubstituted quinolines. 2,4-Disubstituted-8-nitroquinolines, which are important precursors for the synthesis of antimalarial primaquine drug-like molecules, were prepared conveniently by this method in moderate to good yields. Brönsted acid (HClO4)-modified montmorillonite was found to be a crucial catalyst in promoting the procedure.
Graphical abstractHClO4-modified montmorillonite was found to be crucial catalyst in promoting a new domino process of three-component Povarov reaction-aerobic dehydrogenation toward the synthesis of polysubstituted quinolines relevant to antimalarials.Download full-size image
Related Topics
Physical Sciences and Engineering
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Authors
Sankar K. Guchhait, Khyati Jadeja, Chetna Madaan,