Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273706 | Tetrahedron Letters | 2008 | 6 Pages |
Abstract
The first report of a Brønsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate [(HMIm)BF4], catalyzed efficient and chemoselective N-Boc protection of various amines using (Boc)2O is presented. Optically pure amino alcohols and amino acid esters were converted efficiently to their corresponding optically pure N-Boc derivatives. The reported method is mild, solvent-free and has the advantages of both homogeneous and heterogeneous catalysis with high product yields, selectivity and ease of product separation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sadula Sunitha, Sanjit Kanjilal, P. Srinivasa Reddy, Rachapudi B.N. Prasad,