Article ID Journal Published Year Pages File Type
5273709 Tetrahedron Letters 2008 5 Pages PDF
Abstract
An efficient metal-free catalytic protocol for the electrocyclization of α-alkoxydienones to cyclopentenones (Nazarov reaction) in near to quantitative yields is described. The key parameters are the use of inexpensive 4-toluenesulfonic acid in 5 mol % at room temperature in acetonitrile or under solvent-free conditions. The versatility of the transformation is demonstrated with unpolarized dienones with good regioselectivities and excellent yields.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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