| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273726 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Protein synthesis is one of the key and validated antibacterial targets and its inhibition has led to the development of highly successful clinical drugs. Ribosomal protein S4 (RPSD) is a part of ribosomal machinery and a new potential target for antibacterial agents. Screening of microbial extracts using antisense sensitized rpsD strain in Staphylococcus aureus followed by chemical analysis led to the isolation of a new compound lucensimycin C, which is a key biosynthetic intermediate of the other lucensimycins. Isolation, structure elucidation, antibiotic activity, and biogenesis have been described.
Graphical abstractIsolation, structure elucidation, antibiotic activity, and biogenesis have been described.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sheo B. Singh, Deborah L. Zink, Kithsiri B. Herath, Oscar Salazar, Olga Genilloud,