| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273749 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A convenient one-pot synthesis of enantiopure (R)-2-amino-3,3,3-trifluoro-2-methyl-N-phenylpropanamide derivatives has been developed. The key step in this synthetic methodology turned out to be the amide formation in which (R)-2-amino-3,3,3-trifluoro-2-methylpropanoic acid hydrochloride was simultaneously protected and activated by Vilsmeier reagent.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tian-Wen Li, Pei-Hua Shang, Chang-Mei Cheng, Yu-Fen Zhao,