Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273755 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
Synthesis of d-threo-hydroxyaspartic acid, orthogonally protected and compatible with an Fmoc solid-phase peptide synthesis strategy is reported. This synthetic procedure starting from (2R,3R)-dimethyltartrate is adaptable to a multi-gram scale. 2,2-Dimethyl-5-oxo-1,3-dioxazolane formation between the β-hydroxy alcohol and the β-carboxylic functions constitutes a key step of the differentiation of the two acidic functions allowing the preparation of (2R,3R)-Fmoc-β-hydroxyaspartic α-allyl ester.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Boyaud France, Viguier Bruno, Inguimbert Nicolas,