| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273798 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
The Letter describes the investigation of an industrial reaction of N-methylphenylpiperazine and chloronicotinonitrile, under microwave heating. Besides the formation of the expected 2-(4-methyl-2-phenylpiperazinyl)pyridine-3-carbonitrile (4), extension of the scale leads to unexpected by-products. A specific pathway due to the formation of a reactive 'ionic alkylating intermediate' formed in situ under microwave conditions is proposed to explain the results observed.
Graphical abstractAn industrial reaction of N-methylphenylpiperazine and chloronicotinonitrile was investigated under microwave heating.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christelle Lamazzi, Armelle Dreau, Christel Bufferne, Christine Flouzat, Patrick Carlier, Rob ter Halle, Thierry Besson,