Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273842 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
A practical synthetic procedure to hydrolytically cleave the C,C-double bond of α,β-unsaturated aldehydes and ketones has been developed. Secondary amines are employed as organocatalysts for the retro-aldol process under simple and mild reaction conditions. Beside the generation of the parent aromatic aldehydes, the synthetic procedure has been successfully used in a one-pot reaction sequence to convert simple cinnamaldehydes into their α-aryl/alkyl substituted derivatives.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dieter Enders, Thanh V. Nguyen,