Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273843 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
An efficient approach for the parallel solid phase synthesis of isoxazole and isoxazoline derivatives has been developed. The isoxazoles and isoxazolines were constructed through a 1,3-dipolar cycloaddition reaction of nitrile oxides, with resin-bound alkynes or alkenes. The cycloaddition reaction conditions performed on solid phase supports was optimized, and an array of resin-bound carboxylic acid building blocks was utilized for distinct conversions. This methodology presents a new alternative to the diversity oriented synthesis of disubstituted isoxazoles and isoxazolines different from existing routes which are limited in structural diversity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sureshbabu Dadiboyena, Adel Nefzi,