Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5273849 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
A convenient and efficient decarboxylative ketone aldol condensation of malonic acid half esters was reported. In the presence of catalytic amount of triethylamine, a series of aromatic and alkyl trifluoromethyl ketones were transformed into the desired adducts in 61-99% yields. In a preliminary experiment, a moderate stereoselectivity was obtained. Direct reduction of the aldol product with LiAlH4 afforded trifluoromethylated 1,3-diol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-Juan Li, Heng-Ying Xiong, Ming-Qing Hua, Jing Nie, Yan Zheng, Jun-An Ma,