| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273929 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
A convenient access to enantiopure β-amino ketones through a multicomponent reaction of dialkyl zinc reagents, cyclic enones and chiral N-tert-butanesulfinimines is disclosed. Four diastereoisomers can be selectively obtained by the appropriate choice of the chiral ligand (L or ent-L) and the chiral N-sulfinimine (RS or SS). The protocol is particularly efficient when enolisable N-sulfinimines are used.
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