| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273938 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A novel and expeditious synthetic protocol for functionalized pyrimidines using unprotected aldoses as biorenewable resources is reported. The synthesis involves aza-Michael addition of aromatic amines to aldose-derived 1,3-oxazin-2-ones(thiones) followed by dehydrative ring transformation to afford 4-polyhydroxyalkylpyrimidin-2-ones(thiones) in excellent yields. This is a one-pot Montmorillonite K-10 clay-catalyzed amine-driven process proceeding under solvent-free microwave irradiation conditions.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lal Dhar S. Yadav, Chhama Awasthi, Vijai K. Rai, Ankita Rai,