| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5273964 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo[1,2-b]pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
A. El Akkaoui, J. Koubachi, S. El Kazzouli, S. Berteina-Raboin, A. Mouaddib, G. Guillaumet,