| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274024 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
A novel protocol for the organocatalytic conversion of arylglyoxals into the corresponding α-hydroxy arylacetic acid methyl esters has been developed. The catalyst consists of a combination of a commercially available cinchona alkaloid derivative and an achiral thiol and leads to enantiomerically enriched products (eemax 83%) under mild reaction conditions. The alkaloid can be easily recovered and reused without loss in activity and selectivity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ellen Schmitt, Ingo Schiffers, Carsten Bolm,