| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274030 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu.
Graphical abstractAn immobilized Tamiflu analog for affinity chromatography was synthesized to identify possible endogenous target proteins in vertebrates.Download full-size image
Related Topics
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Authors
Yasuaki Kimura, Kenzo Yamatsugu, Motomu Kanai, Noriko Echigo, Takashi Kuzuhara, Masakatsu Shibasaki,