| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274079 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
An efficient and practical method for highly diastereoselective synthesis of 2-quaternary anti-1,3-diol units with three adjacent stereogenic carbon centers has been developed. The reactions proceed regiospecifically at room temperature via samarium diiodide-promoted tandem Aldol condensation and Evans-Tishchenko reduction. The relative stereochemistry of the resulting 1,3-diol monoesters is identified by X-ray crystallography.
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