Organocatalytic enantioselective domino synthesis of highly functionalized cyclohexanes with an all-carbon quaternary stereocenter

A highly enantioselective organocatalytic domino Michael/aldol reaction is presented. The reaction is catalyzed by chiral amines and gives access to highly functionalized cyclohexanes with one all-carbon quaternary stereocenter and multiple chiral stereocenters in high yields and 83–98% ee.

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