| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274102 | Tetrahedron Letters | 2009 | 4 Pages |
Abstract
Nickel/Lewis acid binary catalysis is found effective to direct regioselective alkenylation of imidazoles through C-H bond activation and stereoselective insertion of alkynes. Use of P(t-Bu)3 as a ligand allows exclusive regioselective C(2)-alkenylation, while PCyp3 is found effective for C(5)-alkenylation of C(2)-substituted imidazoles. The reaction demonstrates a broad scope of imidazoles and internal alkynes to give trisubstituted ethenes highly regio- and stereoselectively in modest to good yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kyalo Stephen Kanyiva, Florian Löbermann, Yoshiaki Nakao, Tamejiro Hiyama,