| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274124 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
Domino Heck-aza-Michael reactions are an efficient method for the rapid synthesis of functionalised N-heterocycles. An asymmetric version of this domino process has been developed to access chiral 1,3-disubstituted N-heterocycles from amino acid precursors in excellent yields (68-81%) with moderate to high diastereoselectivity (up to 92% de).
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel L. Priebbenow, Scott G. Stewart, Frederick M. Pfeffer,