Article ID Journal Published Year Pages File Type
5274127 Tetrahedron Letters 2012 6 Pages PDF
Abstract
A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot synthesis of densely functionalized piperidine scaffolds has been developed based on a low-cost and environmentally benign Bi(NO3)3·5H2O catalyst via tandem reactions of 1,3-dicarbonyl compounds, aromatic aldehydes, and amines in ethanol at room temperature. Mild reaction conditions, good yields, high diastereoselectivity, operational simplicity, and the absence of tedious separation procedures, clean reaction profiles, high atom-economy, inexpensive starting materials, and environmentally benign catalyst are the key advantages of the present protocol.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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