Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274127 | Tetrahedron Letters | 2012 | 6 Pages |
Abstract
A simple, straightforward, and highly efficient diastereoselective multicomponent one-pot synthesis of densely functionalized piperidine scaffolds has been developed based on a low-cost and environmentally benign Bi(NO3)3·5H2O catalyst via tandem reactions of 1,3-dicarbonyl compounds, aromatic aldehydes, and amines in ethanol at room temperature. Mild reaction conditions, good yields, high diastereoselectivity, operational simplicity, and the absence of tedious separation procedures, clean reaction profiles, high atom-economy, inexpensive starting materials, and environmentally benign catalyst are the key advantages of the present protocol.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Goutam Brahmachari, Suvankar Das,