Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274191 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Cyclization of 1,3-bis(Ï-bromoalkyl)-5-bromouracil with p-methoxybenzylamine or sodium sulfide led to a series of pyrimidinophanes containing heteroatoms in bridges. An unusual behaviour of the 5-bromouracil ring, namely its contraction into hydantoin units during the cyclization reactions with p-methoxybenzylamine was observed. Sodium sulfide does not affect the 5-bromouracil ring, and no transformation products were observed in the synthesis of pyrimidinophanes with sulfur bridges. A possible reaction mechanism is given.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anton E. Nikolaev, Vyacheslav E. Semenov, Dilyara R. Sharafutdinova, Yurii Ya. Efremov, Vladimir S. Reznik,