| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274215 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-Nâ²-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Raman Vysabhattar, K.N. Ganesh,