Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274230 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was stereoselectively constructed by the cascade Overman rearrangement of a vicinal allylic-homoallylic diol derived from d-tartrate.
Graphical abstractThe chiral and stereoselective total synthesis of A-315675 1, an antiinfluenza agent, is described. The vicinal diamino moiety in 1 was constructed in a one-step reaction by the cascade sequential Overman rearrangement of a vicinal allylic-homoallylic diol derived from d-tartrate.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takayuki Momose, Naoto Hama, Chiharu Higashino, Hideyuki Sato, Noritaka Chida,