Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274283 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
The total synthesis of Resolvin D1, a potent endogenous anti-inflammatory lipid mediator derived from docosahexaenoic acid, has been achieved. The chiral hydroxy-groups at C7, C8 and C17 were obtained via a chiral pool strategy from 2-deoxy-d-ribose. Wittig reactions followed by a modified Pd0/CuI Sonogashira coupling and Zn(Cu/Ag) cis-reduction completed the total synthesis of Resolvin D1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ana R. Rodriguez, Bernd W. Spur,