| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274338 | Tetrahedron Letters | 2009 | 4 Pages |
3,4-Dihydropyrimidin-2(1H)-one, 3,4-dihydropyrimidin-2(1H)-thione, and 3,4-dihydropyrimidin-2(1H)-imine derivatives were synthesized by modified Biginelli cyclocondensation reaction in a time-efficient manner with near quantitative yields starting from appropriately substituted aromatic aldehyde, β-ketoester and either urea, thiourea or guanidine as constituent synthons using tetra-butyl ammonium bromide (TBAB) as catalyst for the first time.
Graphical abstract3,4-Dihydropyrimidin-2(1H)-one, 3,4-dihydropyrimidin-2(1H)-thione, and 3,4-dihydropyrimidin-2(1H)-imine derivatives were synthesized by modified Biginelli reaction from appropriately substituted aromatic aldehyde, β-ketoester and either urea, thiourea or guanidine using tetra-butyl ammonium bromide (TBAB) as catalyst for the first time in time-efficient manner and in near quantitative yields.Download full-size image
