| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274401 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent (1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark J. Thompson, Beining Chen,