Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274508 | Tetrahedron Letters | 2011 | 4 Pages |
Abstract
Hetero Michael addition on chiral βâ²-amino-α,β-unsaturated ketone furnished, after some structural modifications, β,βâ²-diaminoketals. Mannich type reaction of these diamines with an aldehyde led, with a high diastereoselectivity, to trisubstituted piperidines. Starting from a functionalized aldehyde and after subsequent deprotection of the amino group, an intramolecular Michael addition provided octahydro-2H-pyrrolo-[3,4-b]-pyridine, an uncommon framework found in compounds exhibiting biological activity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aurélie Plas, Isabelle Abrunhosa-Thomas, Pierre Chalard, Yves Troin,