Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274532 | Tetrahedron Letters | 2011 | 5 Pages |
Abstract
We report on the chemoselective coupling between colorless peptide fragments functionalized with a mutually reactive electron-rich Nα-(4-ethynylphenyl)-Nα-(methyl)-glycyl- and an electron-deficient [4-(2,2-dicyanovinyl)]benzoyl moiety. The resulting donor-substituted 1,1-dicyanobuta-1,3-dienes represent a new class of orange-red colored (λmax = 450-500 nm, with molar extinction coefficients (ε) above 5,000 molâ1 dm3 cmâ1) peptide-based imaging chromophores.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dirk T.S. Rijkers, Fernando de Prada López, Rob M.J. Liskamp, François Diederich,