Article ID Journal Published Year Pages File Type
5274542 Tetrahedron Letters 2011 4 Pages PDF
Abstract

The indoline scaffold of hypoxia selective prodrugs of DNA-alkylating agents related to the duocarmycin natural products was synthesized via an enantioselective Friedel-Crafts alkylation. Easily accessible starting materials and good stereoselectivity in the alkylation step provide an enantioselective synthesis of the DNA-alkylating subunit.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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A new enantioselective approach to the core structure of hypoxia selective prodrugs related to the duocarmycins
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