| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274661 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
A highly chemoselective substitution on 4-amino-6-chloropyrimidine ring system having a competing aldehyde functionality has been realized with anilines which produces 4, 6-diaminopyrimidine-5-carbaldehyde in high yield. The reaction may involve the intermediacy of imines. A variety of aromatic amines participate in this reaction successfully to generate diaminopyrimidine aldehydes in moderate to high yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anusuya Choudhury, Hongfeng Chen, Christopher N. Nilsen, Kirk L. Sorgi,