| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274672 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
The Ugi four-component condensation between methyl o-formylbenzoates 1, anilines 2a-c, isocyanides 3, and trimethylsilyl azide (4) afforded the expected Ugi adducts 5a-d, which were cyclized to the title compounds 6a-d upon treatment with sodium ethoxide in ethanol. Starting from aralkyl- or alkylamines 2d-g the Ugi adducts underwent a spontaneous cyclization to tetrazolyl-isoindolinones 6e-j.
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Authors
Carlos F. Marcos, Stefano Marcaccini, Gloria Menchi, Roberto Pepino, Tomás Torroba,