| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5274849 | Tetrahedron Letters | 2008 | 4 Pages |
Abstract
Chimeric oligonucleotides with the novel morpholino modification and the phosphoramidate linkers have been synthesized and characterized. These oligonucleotides showed moderate thermal stability with complementary RNA and DNA, and enhanced resistance toward the nuclease (t1/2Â >Â 10Â h). The phosphoramidate linker made the synthesis of such oligonucleotides applicable on a DNA synthesizer. Under the acidic condition (pH 3.0), the phosphoramidate linkers were readily cleaved, and such property might be useful for the DNA-sequence determination.
Graphical abstractThe synthesis and properties of morpholino chimeric oligonucleotides is reported.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nan Zhang, Chunyan Tan, Puqin Cai, Yuyang Jiang, Peizhuo Zhang, Yufen Zhao,