Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274861 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-catalyst. Further, these molecules exhibited interesting DNA-binding affinity profiles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ahmed Kamal, S. Prabhakar, N. Shankaraiah, Ch. Ratna Reddy, P. Venkat Reddy,