Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5274876 | Tetrahedron Letters | 2008 | 5 Pages |
Abstract
A variety of 2,4-disubstituted-5-acetoxythiazoles were prepared from the substituted methyl benzoates in good to moderate yields using a three-step sequence: (1) ester to thionoester conversion, (2) coupling with an amino acid, and (3) acetic anhydride mediated cyclization. In situ hydrolysis and alkylation of 2,4-disubstituted-5-acetoxythiazoles afforded the corresponding thiazolones and 2,4,5-trisubstituted thiazoles. This methodology can be readily applied to the synthesis of thiazole-based chemical libraries.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Q. Qiao, R. Dominique, R. Jr.,