Article ID Journal Published Year Pages File Type
5274876 Tetrahedron Letters 2008 5 Pages PDF
Abstract

A variety of 2,4-disubstituted-5-acetoxythiazoles were prepared from the substituted methyl benzoates in good to moderate yields using a three-step sequence: (1) ester to thionoester conversion, (2) coupling with an amino acid, and (3) acetic anhydride mediated cyclization. In situ hydrolysis and alkylation of 2,4-disubstituted-5-acetoxythiazoles afforded the corresponding thiazolones and 2,4,5-trisubstituted thiazoles. This methodology can be readily applied to the synthesis of thiazole-based chemical libraries.

Graphical abstractDownload full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , ,